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Cagliari Calcio come into this fixture as slight favourites, sitting 12th with 28 points and showing strong home form, including back-to-back clean sheets at Unipol Domus. US Lecce are 17th with 21 points and under pressure, struggling badly away from home with over 300 minutes without an away goal and three straight scoreless away defeats. Cagliari also have the edge historically, winning the reverse fixture 2–1 in September 2025, while Lecce haven’t won a league match in Cagliari since 2012.
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